Calmepam 3 mg 20 Tablets

Bromazepam……….1.5 and 3 mg
Description
Anxiolytic and sedative
Properties/Actions
Calmepam is a paridylbenzodiazepine compound which has anxiolytic, muscle relaxant, sedative, hypnotic, anticonvulsant, and amnestic effects.
Indications
Calmepamis indicated in:
Anxiety
Tension state and agitation
Control of muscle spasm
Management of alcohol withdrawal symptoms
Patients undergoing minor surgical procedures, endoscopy and cardioversion
Insomnia due to anxiety
Functional disturbances of the cardiovascular system, such as pseudoangina pectoris, precordial anxiety, tachycardia and emotiogenic hypertension
Functional disturbances of respiratory system, such as dyspnea and hyperventilation
Functional disturbances of the genitourinary tract, such as irritable bladder and urinary frequency
Functional disturbances of the gastrointestinal tract such as, epigastric pain, irritable bowel syndrome and ulcerative colitis
Ccases of neurodermatitis and eczema, as well as, in the treatment of psychogenic headache and psychosomatic disorders.
Contraindications
Calmepamis contraindicated in:
Patients with known sensitvity to benzodiazepines
Acute pulmonary insufficiency
Respiratory depression
Phobic or obsessional states
Chronic psychosis
Drug Interactions
Side Effects/Adverse Effects
Common adverse effects include drowsiness, sedation, unsteadiness and ataxia; these are dose related and may persist into the following day, even after a single dose.Drowsiness may be a particular problem when Calmepam is used in higher dosage in some patients, especially if they are unused to this form of therapy.The elderly are particularly sensitive to the effects of centrally depressant drugs and may experience confausion, especially if organic brain changes are present; dosage of Calmepam should not exceed one-half that recommended for other adults.Other adverse effects are rare and include headache, vertigo, hypotension, gastro-intestinal upsets, skin rashes, casual disturbances, changes in libido, and urinary retention. Isolated cases of blood dyscrasias and jaundice have also been reported.
Pregnancy & Lactation
There is no evidence as to drug safety in human pregnancy, nor is there evidence from animal work that it is free from hazard.Do not use during pregnancy, especially during the first and last trimesters, unless there are compelling reasons.The administration of high doses or prolonged administration of low doses of benzodiazepines in the last trimester of pregnancy has been reported to produce irregularities in the foetal heart rate, hypotonia, poor sucking and hypothermia in the neonate.Benzodiazepines have been detected in breast milk. If possible, the use of Calmepam should be avoided during lactation.
Dosage & Administration
The following is generally recommended.Adults:
The optimum dosage and frequency of administration should be based on the individual patient, the severity of the symptoms and previous psychotic drug history.
The usual dose in general practice is from 3 mg to 18 mg daily, in divided doses.
In exceptional circumstances, in hospitalized patients, up to maximum daily dosage of 60 mg, in divided doses, may be given.
Elderly:
Elderly patients are more sensitive to the actions of Calmepam. Doses should not exceed half normally recommended.
The lowest dose which can control symptoms should be used. Treatment should not be continued at the full dose beyond 4 weeks. Long-term chronic use is not recommended.
Treatment should always be tapered off gradually. Patients who have taken benzodiazepines for a prolonged time may require a longer period during which doses are reduced.
Specialist help may be appropriate.
Children:
Not intended for pediatric use.