** One-Alpha® (Alfacalcidol) 0.25 mcg 30 Capsules. Vitamin D Analogue (1-alpha- hydroxy-vitamin D3).
** Composition:
Each capsule contains:
Alfacalcidol (1-alpha-Hydroxy-Vitamin D3) 0.25 mcg
** Indications:
Diseases caused by disturbances in the calcium metabolism in consequence of reduced endogenous production of 1.25-dihydroxyvitamin D3. Renal osteodystrophy, postoperative idiopathic hypo-parathyroidism, pseudohypoparathyroidism, as an adjunct to the management of tertiary hyperparathyroidism, vitamin D-resistant nutritional rickets or osteomalacia, vitamin D-dependent rickets, neonatal hypocalcaemia or rickets, malabsorption of malabsorption of calcium, labosteoptsorption , and osteomalacia.
** Dosage:
Initial dose: Adults && children above 20Kg weight: 1mcg daily, Children under 20Kg body weight: 0.05mcg/Kg/day, Neonates: 0.1mcg/Kg/day.
– It is important to adjust the doasge according to the biochemical responses to avoid hypercalcaemia. Incides of response include levels of seum calcium, alkaline phosphatase, parathyroid hormone, urinary calcium excretion as well as radiolographic and histological investigations. Patients with marked bone disease (other than those with renal failure) may tolerte higher doses without developing hypercalcaemia. However, failure of the serum calcium to rise promptly in osteomalacic patients does not necessarily mean that a higher dose is required, since calcium from increased intestinal absorption may be incorporated into demineralized bone.
– Most patients will respond to doses between 1 and 3 mcg daily. The dose requirements generally decrease in patients with bone disease when there is biochemical or radiographic evidence of bone healing and in hypoparathyroid patients after normal serum calcium levels have been obtained. Maintenance doses are generally in the range of 0.25-2 mcg daily.
– Patients currently taking barbiturates or other anticonvulsants may need larger doses of One-Alpha to produce the desired effect.
** To be used only on medical advice.
See enclosed directions for use and dosage.
** Store at controlled room temperature (15 degrees C – 25 degrees C). Protect from direct sunlight.
Keep out of reach of children.
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